Re: F-91W
Just for reassurance, my 2024-vintage F-91W is no more clued up!
151 publicly visible posts • joined 1 Jun 2011
E = E0 + (RT/vF) * ln((a(A)*a(Bv+)/(a(Av+)*a(B))) where E0 is standard EMF, R gas constant, F Faraday constant, v number of charges in the reaction and a() activities of reactants A and B.... according to Atkins.
So it's proportional to absolute temp (Kelvin), which gives us a drop to 78% going from +25 to -40C. I guess there's more loss than that due to electrolyte viscosity etc alluded to in previous posts.
> decent diesel generator in the EV's boot.
I'd fancy a trailer with sled and dogs...
Now there's a word I haven't seen for a while. In the olden days when chemists used burettes and washbottles and got jobs with the Water Board, they were taught about such things. Apparently soft water, as seen in areas fed from peat covered volcanic geology like western Scotland and north-west England, contains organic acids that do lift a bit of lead off the pipes so flushing is not a bad idea. In hard water areas (on chalky ground) the minerals tend to coat the inners of the pipe so there is less of a danger. In the cities of course, you got plenty of lead from the dust in the car exhausts anyway.
> run cold tap for a minute to flush the water from house lead pipes
Or you might think that Pharma has been round this loop before with "new drug bonanza" methods and (a) doesn't want to saddle itself with datacentres and compute farms if it's a dud (b) knows very well what its internal strengths and weaknesses are and realises to get moving it needs external expertise.
See also the Boehringer/IBM story a couple of days ago. I wouldn't be surprised to see more hook-ups like this.
The use of AI for generation of new candidate therapeutics is unlikely of itself to be a threat - this is the start of the process before all the effectiveness and safety testing. Most of the previous approaches have the same problem that they generate many candidates from which you then have to pick the winners. It's not like Pharma hasn't done that before (and we all know what happens when it goes wrong) so I'd be more worried about AI being used to interpret effectiveness or safety testing data.
The antibodies slant does seem to be a novelty - most drugs are "small" molecules that fit like a key in a lock to disrupt some process. Antibodies are much bigger and work the other way round, by enveloping themselves round or sticking to a smaller entity (epitope). Historically, drugs were made by chemists and antibodies by biologists - it's only relatively recently that antibodies have been recognised as potential disease fighting molecules*. The classical way of making an antibody is by immunising a person, or animal. This is a very hit and miss process but its mechanisms are becoming better understood through systems like Alpha Fold, so I can see why AI would be a good bet to move the field on in a rational direction.
It's not going to reduce lab coats though - still got to make and test the things!
* Though anti-toxins and anti-venoms have been used for specific purposes for about a century.
I guess for "default" read "lowest common denominator". If the Calamares installer is the same as Debian uses, then the Manual Partitioning option in the install will allow for separate /home, on a separate drive etc.
Not sure how much swap partitions are used these days.
I've got a box of (recycled) floppy disks on my office, marked Debian 1.2.8. I obviously didn't think the Toy Story names would catch on.
Having been "out" of Linux for a while I'm now getting used to Bullseye on slightly more modern hardware. But I didn't have any more difficulty installing the recent versions than I remember of the old.
Beer icon for all those people who made it so easy!
Depends on your local water supply and probably your cleaning regime what grows on your surfaces. The pink stuff is produced by (the Bacterium Formerly Known As) Serratia marcescens, which is an occasional pathogen, so I can see an allergy problem coming up here if you start putting it on your skin.
Think I'll wait for space travel to get to Business Class comfort rather than Backpacker before I sign up!
If you regard $_ as "subscript" and replace {} with (), it turns into a completely regular chemical formula.
The basic ingredients are two metals found in scrapyards, and phosphate, available from piss.
I expect a slew of unsavoury youtube videos and another epidemic of cable thefts and church roof stripping...
Oh, yes, definitely! Although perhaps it was the bandwidth limitation of a serial line or 28K modem in those days that allowed me to get the message before going mad.
Some years ago it was the fashion to have a big bay window and no curtains, so any passer by could see what you wanted to show off. Now I notice more people seem to be going back to curtains and blinds. Perhaps the next generation of social media will include that.
We got a fancy piece of analytical kit. About 3 or 4 years later the supplier came with an improved design of its "Injector". As we had a bit of budget slack and it wasn't too expensive, I laid out for it. Of course I kept the old one in a box in the back of a cupboard on the basis that new improved doodads sometimes aren't any such thing, but it was fine. The old one stayed in the cupboard and survived several tidiers up, put off by a low but menacing growl.
So about a decade later, an email arrives from the supplier's senior service engineer: "You wouldn't be any chance still have...?" Of course I did. I never got a clear explanation of why they wanted an old one, except that it was a customer demand, but I did get a full service on the machine (long out of contract) and the sort of intangible brownie points with the supplier that have kept the system in service on a tight budget since. And a good story to tell the whipper-snappers that come round from time to time poking in my cupboards!
I'd be happy if they applied the same sort of effort to the help systems in 365 itself. Every time I use it, there is a guaranteed 10 minutes fighting to work out where some option has gone. I can see how this will go:
"How do I remove the green shading on the bullet points?"
"I'd advise rewriting your whole document with a more punchy stakeholder oriented style. Can I do that for you?"
> Part of its design is that it should be useful to people who have only intermittent or limited internet access, and that the computer is still useful when offline.
This could be a selling point for PCs that you can't/don't want to network continuously. All the other distributions I'm familiar with assume an internet connection will be available for updates. While most can be *installed* off a downloaded ISO or similar, updating an "air gapped" PC is basically limited to reinstalling the whole lot. (I know there has been some effort to get round this but it does not seem to have got too far.)
> Updates are handled by the Red Hat-developed OStree tool.
I'm not familiar with this, it would be nice to know more.
> Just asking, how could someone be 'meaningfully' impacted if twatter,failbook and their ilk would collapse?
You might fall off your chair laughing, and crack your head on something. Or you might become distressed at the sight of all those media regurgitators (looking at you BBC) scratching around for flingable crap.
> As light hits various elements, they reflect different wavelengths,
No, as the light passes *through* the atmosphere, various elements and (mostly) molecules *absorb* different wavelengths.
This creates a transmission spectrum as explained in the NASA article. The observations can only be made when the exoplanet is passing in front of the star. Reflection would require the exoplanet to be behind or lateral to the star, and isolating the planet's effect is impractical in that situation. I suppose fluorescence or phosphorescence might conceivably be usable but I don't know if JWST could do that.
If you look closely at your tea kettle cord, you should find various national approval body markings (DIN, BSI, UL...) showing that it won't set your house on fire, at least in normal use. I wonder how long before insurance companies start looking at this and requiring the same sort of certification for high power PC accessories?
Obvious icon!
Even if AlphaFold were a silver bullet, expecting new drugs this soon would be a bit premature - there's a lot more work than the protein structure. However AlphaFold is becoming a productive tool for structural biologists - a structure prediction having an indication of confidence is helpful in tailoring the wet lab experiments towards avenues likely to succeed. As with many things, ignore the hype and find out what it can realistically do.