2702 posts • joined 24 Mar 2010
Re: "Do you have a ref. for this. What in deity's name is a 'reverse catalyst' ??"
Let me be clear on this, at least for others. A catalyst only increases reaction rates (in either direction equally ) by lowering the activation energy. The system will reach its tthermodynamic equilibrium ( at the temp/pressure it's under) faster. It's a kinetic effect.
Re: I'm confused.
"Template-based modelling, however, only works if there is another well-known protein that is comparable"
However there are many in-between cases. One of the best ones I know are the prediction of the beta-propeller structure in integrins from other beta-propellers where the sequence match is rather poor.
Re: Grail seekers
"There's no Holy Grail, just a lot more work."
It would be nice to think there was but having spent 10+ years modeling proteins I tend to agree it's hard.
Incidentally the most important property of a sequence is probably to fold quickly and cleanly. Efficient function is nice to have.
"Dark matter has an effect on gravity, gravitational waves are a change or variation in/of gravity."
AFAIK gravitational waves distort spacetime and change lengths & time as they pass. They are not in themselves 'gravity'
A lot going on here so I've not been able to refresh my memory on this.
Re: How are these supposed to save energy
"Microwaved some coffee, put a spoonful of brown sugar in it, ,,, and WHOOSH"
It's essentially an example of kinetic v thermodynamic effect. Thermodynamically the water has enough ( more than ) energy to boil but no initiating pathway. In the lab we used little fragments of glass or wooden sticks ( added before reaching boiling I might add) to promote smooth boiling. Your sugar just trigger very rapid boiling. Almost like a mild explosion in fact. Cryogenic liquid gases added to room-temp water can sometimes behave in a similar manner - the initial turbulence promoting more and more rapid mixing until the evolution of gas become very violent.
Linux kernel Spectre V2 defense fingered for massively slowing down unlucky apps on Intel Hyper-Thread CPUs
Re: Quantum navigation
"So it knows *where* it is, but it doesn't know how fast it's going? Or the other way around?"
But if it has a fixed position at time T and then T+x ( where x might be quite small) then the direction and travel are a trivial calc. That's what my hand-held GPS ( 14+ years old I'd guess) has always done.
Has science gone too far? Now boffins dream of shining gigantic laser pointer into space to get aliens' attention
Apache OpenOffice, the Schrodinger's app: No one knows if it's dead or alive, no one really wants to look inside
Re: Counting is not so easy.
"Does anyone use Linux on the desktop? </troll>"
Well I'm sitting here in Saas-Fee in Switzerland and I've just used a little GUI window on this Linux desktop to start downloading a number of BBC comedies onto a Pi at home (UK) . After that I'll move them using a GUI filemanager ( using fish: ) to watch here.
"12 people get shot in a school and it's the end of the world (which it is) but 3,000+ die EACH MONTH and it's completely ignored."
Difference is 12 people are shot without any reason WHATSOEVER whilst deaths on the road are one of the risks of everyday life (which we should try and minimize) for which we derive a benefit
Re: Judging by the mugshot I'd say he definitely deserves a "Man In Shed" award.
"Clearly a fellow with a fine shed of delights to work in."
Sheds are called 'stadel' around those parts - although more like a small, massively built, barn.
Our local butcher does a line in what look like small cumberlands pinned with a stick but the machine looks like it is designed for bratwurst or kalbsbratwurst
Re: Why anyway ?
"I remember arriving in Calais by ferry in the early-1980s. It was lunchtime. French border control/customs were no where to be seen."
I passed through a border about the same time - I think it was Lux.-France. There was a border post but all that was visible was the bottom of a large pair of boots hanging out of the box ( officer attached )
Re: Why anyway ?
"France has been scanning passports on leaving the country for a non-Schengen country for as long as I can remember"
That's certainly not true at Calais. The recent terror incidents have often resulted in French troops searching car boots (duplicated by security staff BTW) but no scanning passports as far as I can recall. (I'm usually too annoyed by the size of the queue at UK control.)
Re: Why anyway ?
"issue of "Frontaliers" (people who work in Switzerland but live in France where it's cheaper)"
Indeed when leaving Switzerland via the crossing near Vallorbe at ~0600 I'm always amazed by the number of cars streaming towards Switzerland from what is a relatively sparsely populated area of France. The Swiss have a shortage of all sorts of workers and low unemployment so I can't see this being easily changed.
Re: Why anyway ?
"Switzerland and France are both in Schengen, the UK is not."
I know all about Schengen - I've been enjoying its advantages for years. My point is Switzerland seems to cope with a free movement in highly desirable country without having to record every in/out. It's basically done another way if you want to remain/work. Until France tightened up security at Dover recently* and UK exit checks were introduced it was normal to drive UK-France-Switzerland-Italy and return and show passports once (at UK border in Calais). Before Schengen most European borders involved cursory checks if any.
*Schengen is very strict border controls at the outer border - Oh yes, even now at the French 'border' at Dover the passports are usually just glanced at if at all
Why anyway ?
I travel by road into Switzerland via France 3/4 times a year - nobody checks, we have a holiday and return again without checks ( other than UK) . If Switzerland can manage without being completely overrun how come we have a problem. ( We stay in our own apartment BTW so no checks there either )
2 + 2 = 4, er, 4.1, no, 4.3... Nvidia's Titan V GPUs spit out 'wrong answers' in scientific simulations
Re: I Don't See The Problem
"At the quantum level, there is uncertainty as to position, or even the outcome. It seems these cards are modelling that behavior."
Point is they're not supposed to be doing that. Even if the algorithms generate deterministic chaotic outputs that wouldn't explain 2 cards being OK
Well I've got a mixed estate of 8 Pis
1) is a motion sensitive camera overlooking the back of the house, a temp. sensor reporting to pi2 and an in-house web-server
2) is a file server, iplayer server, runs a daemon that controls 4 remote wireless mains sockets and records temp. measurements from around the house.
3) Has daemon controlling external house-lights via a Power MOSFET, has a temp. sensor reporting to pi2.
4) Motion sensitive camera and PIR sensor.
5) Motion sensitive camera, has a temp. sensor reporting to pi2
6) Controls via Pi2 a heater in otherwise unheated utility room, has a temp. sensor reporting to pi2.
7) has 2 temp. sensors reporting to pi2.
8) testbed - at mo' has a Schmitt trigger light sensor tracking dawn-dusk
Very simple jobs which could be combined into a smaller number but would mean swathes of wiring around the house.
Combining the capabilities can be usefull. Just tracked over the last few weeks an area of loft that had an intruder that sounded
too loud to be a mouse. So PIR detector switched on light and motion cameras spotted a mouse and a few days later noted its demise.
Re: Modular reactors are the only real answer.
"The only realistic option will be a new fleet of subsidised CCGTs, and they will then undermine the case for SMR unless SMR also get subsidies."
Agree entirely. Just a glance at the current load on the grid is quite scary. (OK it's very cold but luckily it's windy). The coal/nuclear contribution is ~40%
"It's bad enough auto-mounting by default"
Well it's just box clear/tick in System Settings to enable/disable automount. There are finer grained options as well if you do want to automount something.
What I can't remember because I always have it turned off is what the default setting for a fresh install is.
"Quite the opposite. It's a tool that is more than good enough for both "proper" software engineering and quick and dirty analysis*. "
Agreed. I worked (~2003) for a while, on secondment, with our Computational Chemists and was suprised at the extensive use they made of Python. Mind we had an extensive set of in-house and commercial libraries, tools etc.
Re: What's the nature of a scorpion?
"Well, it's not like I have something to hide. And besides, who would be interested in pictures of my pet/my holiday?""
Well I've not got anything to hide ( except financial stuff naturally) but I do always use ssh to access my systems at home from outside - this is to ensure security so my systems don't become a playground for spammers etc. My system is as secure as I can make it.
"I would think that the "security agencies" would know that any encryption with a backdoor is useless"
It's the same in other areas. I lost count of the number of times I put together very detailed proposals for/against certain approaches to tackling a disease area, going to great lengths to research what was know, list the unknowns, explain the complexities, list the pros & cons and suggest a way forward only for a PHB+2 to dismiss ( or sometimes sanction ) the whole thing after a few moments consideration.