Re: @Charlie Clark - Davos launches new bid to stay relevant
The antibiotics are cash cows with nothing to come after them when the patents run out. Vaccines only make money at enormous scale, heart disease and the like is where the real money is.
12172 publicly visible posts • joined 16 Apr 2007
I'm sure there are some important discussions at Davos but almost none of them will be about whatever the supposed topic is. This is just to ensure maximum media coverage.
As for future pandemics, well I think the roadmap is currently paved with the best intentions which will all be quietly shelved in a few years when the money runs out. As happened with the previous ones. Standard epidemic protocols are usally a good start and would have been good in 2020 if they'd been followed. And we have got some new tools: regular analysis of waste water can help identify outbreaks fasrter and more reliably than testing, and sample for sequencing and some vaccine approaches that were novel (mRNA, vector, protein, spray) are now proven to work at scale. But we'll have to wait for things to get really bad before any resources are committed.
If we don't do something about the abuse of antibiotics and the rise of resistant bugs, we're really could be back to the 1930s. This is avoidable and solvable but there's not much money in it for Big Pharma when compared with selling antibiotics to the agricultural industry.
For large scale attacks fuzzing is now the weapon of choice. Sure, if a quick static analysis reveals potential vectors, they can be considered nice to have, but the best thing is simply run attacks in a sandbox and keep the results quiet.
Medics are notoriously unqualified to assess the safety of software devices. You really need trained engineers for that who can get the necessary medical information from the clinicians. But we then run into the usual problem: regulators are underfunded and understaffed, so lightweight "self-regulation" usually gets the nod: medical devices, cars, planes, financial products, etc.
It's difficult to see any real path to success here: legally, there's no difference between a medical device and anything else we buy the software can be considered the IP of the manufacturer.
But the data collected by the device is another matter entirely. This should be clearly documented and the patient and/or their clinician should be given the means to access it and control who else has access. This is much easier to legislate and implement.
At some point, even the dimmest bulbs in the C-Suite will realise what they've signed up to with <-- insert provider's name here -->. By being the first to make such an announcement (the details don't matter in such press releases), Google will get the press and very likely some business. The egress & lock-in farce really does need anti-trust investigation but that will take years.
I metered power for hardware next: start with the drivers of electric vehicles who've already got the necessary cards and accounts. And, why don't we go back to metered network use?
I'm sure some companies are already looking at moving from work from home to full company store mentality where everything has to be paid for in BOFHCoins.
Couldn't see anything in the article but Reuters says The transaction is expected to be funded through financing commitments for $14 billion in term loans. In case nobody noticed, we're no longer in a period of zero interest rates, this is going to be very expensive for HPE which will almost have to sell stuff to cover costs because it certainy won't get it from net cashflow.
Czechia has been proposed by the Czech Republic as the English name for the country but they don't get to decide, even though it does make sense: Czechoslovakia was comprised of Bohemia, Moravia and Slovakia. But Czechia doesn't work very well in English and the Polish-style "cz" as the transliteration for "č" has always been odd: "ch" (as in church) would make more sense, which would probably give us "Cheskia" or "Chekovia" or something like it.
Turkey is trying the same with Türkiye, and will have probably even less success.
Cheque/check is just one of those words where a common origin (from the Persian Shah for king, which gave the name to the game and thence to exchequer and the checkboard pattern) where neither spelling is really right because of the range of uses. It's arguable that the french-style "cheque" certainly helps disambiguation when reading but given the prevalence of homophones (they're, there, their, lead and led) (and heterophonic homograms (lead and, er, lead)) in English, I've long given up any hope of "fixing" it!
It's not an airfram incident. It's most likely a customisation issue do to the filling of an emergency door in an aisle. This is why the supplier, Spirit Aviation, is as much on the hook as Boeing. Airbus does not allow this kind of, presumably cost-effective, customisation.
What's the difference? The transition from a high pressure volume to low pressure is both depending on how you frame it. But seeing as how we tend to use blowers in otherwise constant pressure conditions, and suction for sudden changes, I think suction here is the better description.
Quite a lot of the new base stations are self-powered. I guess greater efficiency will allow for more, smaller base stations for more dense coverage. Possibly at some point we might even get fire-and-forget self-configuring stations.
But I don't see networks outside China increasing their spend just to get the new tech. Existing stations will be updated and replaced as and when.
I have a few reference books that I keep around for that reason. But, with the right larger reader, you really don't miss much. I now prefer reading on my Kobo Aura than I do with paper: I can make notes and even flip through pages, though this isn't quite the same as say, going back and forth between a chapter on schema design and triggers.
And, at some point, I imagine I'll have something for the kitchen. There are fewer books that have you flipping back and forth between pages than cookery books, and fewer places less suitable for doing this than a kitchen: operating theatre, laboratory and garage spring to mind.
I have had imy current reader 8 years or so and battery life is still fantastic and SWMBO has the previous one. Slower refresh cycles are probably one of the main reasons why product development hasn't kept pace with that of mobile phones.
Regarding the BBC, rights issues have got worse in the digital age with lawyers hoping to monetise even more parts of the chain and charge as much as each market can bear. Just get a good VPN and Get IPlayer and enjoy things while you can: continuing cuts at the BBC as a result of government policy are really hollowing it out.
I've moved a lot and books are bulky and heavy. I'm down to two bookshelves with my favourite books and some reference works, the rest is digital. I buy more books since I got a reader (Kobo) over a decade ago, though I always strip the DRM.
The BeFS pretty much succeeded: it didn't turn the FS into a database but it made extensive use of file attributes and metadata which meant it felt like a database. For example, the headers of e-mails were exposed as attributes and visible in live queries. This is turn meant applications didn't need to invent their own database and queries. There is a downside to this, of course, because node monitoring introduces an overhead to all file operations as the index is updated. In general, this was not noticeable but, of course, any operation with lots of small files is noticeably slower than on other systems.
Dominic Giampolo wrote a book on the subject and I'm pretty sure that some of the ideas went into Apple's file system which supports queries without routinely trashing the disk to update the index, which Windows still seems to manage.
I got the thing with the wine but wondered where he went wrong with the beer. Anyway, he also missed out on the liqueurs and spirits. Christmas without port and sherry? We must be fucking joking. Just picked up a bottle or marsala to go with the madeira so that we can have the holy trinity. 150 ml of port? Now you're talking!
But I'll need something to go with the coffee to help those mince pies* down, cognac will do nicely. 20 people need 20 cl each, ten bottles ought to do it.
* Stollenkonfekt actually here
Meritocracy was originally proposed as a dystopia and it turns out that people don't like being told what's good for them: I think this applies to us all to differing degrees and it also assumes the scientists can agree. Personally, I think it's best when politicians and technocrats work together and the politicisation of the bureaucracy must be fought against.
Right, but what you say applies to machines that Apple have stopped supporting. Though this is less of an issue now that Open Core is working so well – it's on my reserve MBP 2016 so that I won't feel naked when I eventually update this machine. I guess I could consider doing something with my old MBP 2010 but it's hardly faster than an RPi, uses more power and makes more noise.
As for speed, depends very much what you're doing. Apple's own software for creatives is pretty well optimised. As for anything I install using MacPorts, it doesn't seem to run slower than on comparable Linux systems.
All I need for unix on MacOS is a Terminal. I can even run in non-GUI single-user mode if I'm so inclined.
None of the Linux GUIs I've seen are any better than MacOS and most are a lot worse. There's stuff I don't like about MacOS, especially the dumbing down towards IOS but most things have been pretty consistent over the last 40 years, which is more than can be said for the competition.
Given that MacOS provides a full BSD userland, why bother with all the hassle to run Linux on a machine? The only thing I can think of would be better Docker performance, but you'll soon hit hardware performance problems long before the virtualisation overhead causes problems.
I can understand the project which is doing it because it can, but anyone who wants Linux on ARM should not buy a Mac to get it.
Cue the adverts for Chesters Beer with Dawn French… sadly I've not been able to find them, but along with they're up with the old Boddingtons ones. Personchester wouldn't be called Personchester without Chesters. And to think, back then, that was funny. No doubt there people with too much time on their hands willing to pounce on such obviously sexist place names and they'll probably hold up the supposed origin of Mamcunium (fort between the breasts - the mounds in Castlefield) as evidence!
I suspect the whole thing is an attempt to stop people who've ordered one from cancelling their orders and thus making cashflow even more difficult. Talk up the product to keep the suckers attention. What will the next wheeze be? That, with a small modification or add-on, it can fly?
There's always been competition for private hire services, which is what Uber provides. Taxis are considered in many countries as part of public transport and regulated accordingly. It's true that in some countries, restrictive practices such as the artificial limit of licences apply but the solution to that is simply to change the practice.
Didn't Herbal Life do just that?
I seem to recall that US advertising is generally a free for all with the truth being the first victim. However, regulation means that companies can be held liable for their claims. This is what leads to the schizonphrenic world that is at the same time paranoid about what the FDA might say about the publication of trial data and the massive advertising campaigns for drugs once they've been approved.
Generally unlimited liability tops free speech and the current case against Purdue and the Sackler family may reassert this.