Re: Capacity
You can get heat pumps which will output north of 16kW of heat... if you're losing more than that then you have a serious issue, or a *very* large house (at which point a pair of pumps might be a reasonably option) or you should actually install windows and doors rather than just leaving gaping holes in your property.
A flow temp of 50 degrees will require non microbore pipework to your radiators, but assuming a 20 degree room temperature then you've still got a better thermal gradient radiator-room than room-external with an outside temp of negative 10 - which is not at all common across the vast majority of the UK.